FCPS PART1 MEDICINE PAPER 20th NOVEMBER 2012

1) A patient with a lesion in the nose,granulomas n proteinuria,most likely lesion?

A) Wegner's granulomatosis

B) leprosy

c) sarcoidosis

D ) TB



2) Which one is precancerous lesion?

A) cervical erosion

B) leukoplakia

C) heamarthrosis

d) duodenal ulcer



3) cardiac muscle cannot be tetanized because it has

a) action potential with plateau

b) gap junctions

C) long duration of contraction

d) long refractory period e) automaticity



4) In anion gap calculation NA is multiplied by 2 causes?

A) Anions

B) other cations

C) proteins



5) Which of the following bone is first to ossify ?

A) sternum

B) clavicle

C) humerus

D) femur



6) Anterior fontanela close at ?

A) 6 - 12 months

B) 12- 18 months

C) 18- 24 months

D) 24- 30 months



7) Following causes activation of Cyclic Amp mechanism ?

A) protein pump

B) Ion channels

C) receptors

D) hormone

E) Enzyme



8) which of the following is not in ant. relation to left kidney

a) diaphram

b) pancreas

c) stomach

d) spleen

E) splenic flexure









9) LIver held in its position in the body By?

A) diaphgram

B) peritoneal ligaments

C) inferior vena ceva

D) Falciform ligament



10) Cause of right shift of oxygen dissociation curve ?

A) carbon monooxide

B) fetal hemoglobin

C) decrease PH

D) increase PH



11) Avidin has the greatest affinity ?

A) vitamin A

B) B1

C) biotin

D) B 12

E) vit C



12) highest caloric value ?

A) carbohydrates

B) protiens

C) fats

D) starch



13) Specificity of a test represnts ?

A) true positive

B) true negative

C) false positive

D) false negative



14) a know hypertensive on drug therapy..present in emergency with collapse..her plasma K is 6.1..what is the likely cause of collapse

A..ARF

B..CRF

c...infection

D..diuretics

E..cushing



15) Triglycerides

a. transported by lipoproteins

b. 3 fatty acids having glucose



16) Which part of blood test should be sent for matching histo compatibility of the recipient and donor

1. WBC

2. RBC

3. Bone Marrow

4. Serum

5. Platelets













17) Which type of joint is Pubic Symphysis

1. Sydesmosis

2. Fibrocartilagenous

3. Primary cartilagenous

4. Secondary cartilagenous

5. synarthrosis



18) A tumor which changes its shape size and also reversible

1. Metaplasia

2. Anaplsia

3. Desmoplasia

4. Dysplasia

5. neoplasia



19) Pulse pressure is high in

1. heart Failure

2. haemmorhage

3. Aortic stenosis



20) A woman of 30 years old needs renal transplantation. 5 donors came up for her. Which of the following is best match for organ transplantation

1. Her Identical twin

2. Sister

3. Husband

4. Son

5. Half brother



21) What is correct regarding surfactant

1. Highest concentration in amniotic fluid is in last trimester

2. It decreases lung compliance

3. It forms a layer between maccro molecules

4. it is produced by Type 1 pneumocytes in the last trimester of pregnancy

5. Its production decreases as the size of alveoli decreases



22) prostacyclin is produced by

1. Peyer patches

2. Mast Cells

3. Fibroblasts

4. Endothelial Cells

5. Platelets



23)Thromboxane A2 is produced by

1. Peyer patches

2. Mast Cells

3. Fibroblasts

4. Endothelial Cells

5. Platelets



24) Which activates thirst center

1. ADH

2. Aldosterone

3. Renin

4. Angiotensin

5. ANP



25) Which of the following helps in regulation of sodium absorption

1. Atrial Natriuretic peptide

2. ADH

3. Aldosterone

4. Aldosterone + Atrial Natriuretic peptide

5. Renin



26) What is the rapidly acting antidote for Warfarin

1. VW factor

2. Platelets

3. Vit K

4. FFP

5. Factor VIII



27) Heparin is produced by

1. Plasma Cells

2. Basophils

3. Mast Cells

4. Mesenchymal Cells

5. Fibroblasts



28) What is the treatment of choice for the meningococcal meningitis, if he has no drug allergies.

1. Sulbactum

2. cefazolin

3. penicillin G

4. Ticarcillin

5. Methicillin





29) Which one of the following is helpful in the treatment of the subarachnoid haemmorhage

1. Nifedipine

2. Captopril

3. Nimodipine

4. Verapamil

5. Atenolol



30) In which one of the following disease there is a normal level of parathyroid hormone

1. Singers Nodule

2. Goitre

3. Osteomalacia

4. Osteoporosis

5. Hypothyroidism



31) In ECG what represents a T wave.

1. refractory period

2. ventricular re polarization

3. atrial systole

4. Ventricle diastole

5. Atrial re polarization



32) A 20 years old male feels dypsnea on on lying supine, which one of the following causes this.

1. puberty goitre

2. retrosternal goitre

3. thyrotoxcosis

4. toxic nodular goitre

5. Eu thyroid



33) Which tumor derives all the 3 germ layers.

1. Adenocarcinoma

2. Teratoma

3. Rhabdomyosarcoma

4. Chancroid

5. Bronchogenic Carcinoma



34) Which type of neurotransmitter will you find during slow wave sleep

1. Serotonin

2. Enkephalin

3. Dopamine

4. Endorphin

5. Melatonin



35) Subarachnoid space ends at

1. L1

2. T12

3. L3-L4

4. S2-S3

5. L5



36) Which of the following disease is caused by the bite of mosquito

1. Ochronosis

2. Filariasis

3. Whipple

4. Ascariasis

5. Ascariasis



37) A 32 year old woman with discoid rash, arthritis, and oral ulcers. Which of the following is the choice of test.

1. Anti double strand DNA

2. ANA

3. Warm Antibody test

4. Protein C

5. HLA B 3



38) A 40 year old man, by profession a fiherman, has following CBC report. Hb is 10.4, MCV is 60, Plt is 220. Which of the following is most likely parasite in his body.

1. Ascariasis

2. Diphyllobothrium latum

3. Hook worm

4. Strongyloides stercoralis

5. Scabies



39) COX 2 inhibitor

1. Ibuprofen

2. Indomethacin

3. Meloxicam

4. Piroxicam



40) A 15yr oldboy present with sudden onset generalized purpura.a diagnosis wad made.which one of the lab invt will b imp for diagnosis

1.capillary abnormality

2..platelet count 20.(10)9/L

3.platecount 90.(10)9/L



41) Secondery transport, a. urea b. protien c. amino acid d. glucose



42) leison of pyramid at medulla cause .

1. Balancing

2. motor loss

3. propeception

4. Discrimination loss



43) the fibrous pericardium and serous pericardium receives innervation from

1.vagus nerve

2.phrenic nerve

4.intercostal nerves

5.



44) Increased parasympathetic stimulation wiil cause relaxation of

1.gut walls

2.brochial smooth msc

3.GIT shincters

4.urinary bladder msc

5.pupillary shincter



45) external juguler vein is formed by

1. behind angle of mandible over the surface of sternocleidomastoid

2.union of posterior division of retromandibular vein and anterior auricular vein

3.have no tributaries



46)In insulin deficiency

1. Liver produces ketones



47)Which reflex in defecation

1. anorectal

2. rectoanal



48) Enzymes which transfer radical from one molecule to another

*hydrolases

*oxidoreductases*

*transferases



49) question abt igA nephropathy

* increased mesnagial mass

* thicked Basemnt meb

*fused podocytes



50) melanoma risk increase in

*xeromantum pignosum



51) ant triangle sensory supply (dermatome)

*c2 c3

*c3 c4

*c2

*c4



52) pathologenic method of virus?

* alterations in proteins

* free radical formation





53) sicle cell disese

* hb s factor

*leukocytosis



54) sympthetic muscrainc supply

* sweat glands



55) glucagon increase in

* exercise

* free fatty acids



56)‎ 8th cervical sympt loss

*partial ptosis



57) soldier came from high attitude, drug ?

* acetazolamaide(Ans)

* erythropaoitn



58) in exercise.. one of the following did nt get full blood supply ?

* kidney

* skin

* brain

*heart

*skeletal muscles



59) cerebeelum injury will cause inabilty of following except

* rapid movements

* co ordination of shoulder joint to raise hand

*initiate the movement

* can stop finger beyond the target



60) basal ganglia injry ( not apropriate)

atony of bladder

limba jerky movent swinging of hands

flat face intension tremors



61) beta endorphins found in

* basal ganglia

*thalamus

*hypothalamus

*brainstem



62) pharngeal swalloing

* palatophrangeal arch go lateraly

* larynx moves donward

*vocal cords approximated

*phrngeooesophageal sphincter contracts (Ans)?



63)muscular dystrophy wat is true

* duthchen type is x linke ressive



64) blood pressure increased frm 140/80 to 160/100/.. change in csf?

* no change in cerebralflow

* csf flow rate inc

* csf formation inc

* cushing reaction



65)stroke vol increased by

* diastole fall presure

* systolic pressure

* increased contraclity





66) peripheral n cns chemoreceptros

* inc in pco2(Ans)

* dec in o2



67) major paracrine inhibition of gastric hcl

* somatostatin

* gastrin

* histamine

*enterogastrone



68) male pt with breats enlargment, with no erection , increase?

* gonadotropin realasing hormone

* prolactin



69) physiological nystagmus

*intact vestibular system

* cerebellaer sys

* slow in long component



70) myosin head covered by

* tropomyosin( ans) ?

* tropnin C

* trop T



71) scenario... preneoplastic old male genital lesion

* balntidis ...

*lichen simplex c

* HSv



72) scenario pt unable to pass urine..

*atonia bladder

*parasym effernt to bladder

*viscearl effernt to blader



73) steroid hormone action thru

* nuclear mem changes

* genes activation

* cell mem permeabilty



74) Intestinal pain is reffered to

a.umblicus

b.epigastric

c.back



75) Which non vasodilator drug is effective in angina?

A.metoprolol

b.nitroglycerine

c.nifedipine

d.verapamil



76) Regarding inguinal canal what is most approriate

a.it is absent in infants

b.bounded superiorly by cojoint tendon

c.illiohypogastric n pases



78) A man lying naked at operation table with room temprature 21.5 C” and 80% humidity by which mechanism heat transfer from body

a) By Veporization

b) Radiation and conduction (ans)

c) sweating

d) respiration



79) what is the best way of communication between a patient and doctor

a) A clean room

b) Active Listening (ans)

c ) speak Loudly

d) well furnished clinic



80) A man is diagnosed by a fatal illness which has v poor prognosis as a doctor what will u do

a) Hide every thing

b) tell the nature of illness to patient’s family only

c) tell the nature of illness to patient and his family only

d) tell the nature of illness only to the patient

e) Give crispy and evidence based whole information of the illness to patient



81) Atheroma...what is correct...

*core contain proteins

*only cause of ischemic heart disease

*only cause of arteriosclerosis

*More common in males than females





82) ‎20yr old male,smoker on climbing stairs c/o chest pain n dyspnea... Cause of breathlessnes in this patient

*Ventilation perfusion mismatch



83)sever dehydratiin...

A ecf decrease

b intracellular fluid decrease

c plasma decrease

d both ECF and ICF decrease



84) patient known case of HIV present with abdominal distention on aus bowel sounds absent... laprotomy reveals mass in ileum.. (description of mass i dnt remember exactly). diagnosis

* large B cell lymphoma

*hodgkins lymphoma

*metastatic adenocarcinoma



85) which carcinoma do not SPREAD to bones

a)kidney

b)breast

c)prostate...



86)Total Peripheral resistence in a vascular system depends on

a arterial pressure

b microcircution,

c venous tone

d vasomotor tone



87) most commonly associated with HIV

*toxoplasma

*pnemocystic carinii

*HSV

*chicken pox



88) child with skin itching..stool examination reveal worms.. presence of which wd aid in diagnosis *basophils

*eosinophils

*lymphocytes



89) a child with x linked agammaglobulinemia increase risk of infection

*pyogenic

*viral

*fungal



90) which is present in lateral sulcus of cerebral hemisphere

*insula

*opercula

*splenium



91) distal ileum removed..reabsorption decrease

*bile salts

*proteins

*iron



92) most imp feature distinguishing malignant n benign

*metastasis

*invasive n infiltrative margins

*



93) role of granulation tissue in wound healing by secondary intention

* wound contraction

*traps the bacteria



94) which is not true about coronary artery

*anastamose freely in wall of heart

*are first branch of aorta

*blockage result in ischemic heart disease



95) A new borne presented with tachypnea O/E there is decrease breath sound on left side normal breath on right side, chest x ray show gut loops in left side of the pleural cavity what is the likely cause? a) defective pleuropericardial membrane b) atresia of lower esopahagus c) defective pleuroperitoneal membrane d) Hitus hernia e) Dextrocardia



96) Which artry does not suply breast

a.axilary

b.musculophrenic

c.thoracoacromial



97) CSf reabsorption most appropriate

Arachnoid villi

Choroid plexus



98) Child with vomitting, yellow discolaration of sclera,dark coloured urine. Relevant investigation... *hep A n B Serology

*serum bilirubin n ALT

*Alkaline phosphatase

* total bilirubin



99) In autosomal dominant disease

1.both parents of affected child have the disease

2.only one parent of affected child has the disease

3.none have the disease



100) pulmonary capillary wedge pressure

-indirectly measures left atrial pressure

-indirectly measures right atrial pressure

-is named because of wedge shape of catheter



101) most common agent of bacterial peritonitis?

a e coli



102) which is the short term iportant effect of angiotensin II?

a. vasoconstriction

b. stimulation of the thirst center



103) which of the following is responsible for the net reabsorption of sodium in the kidney?

a. aldosterone

b. atrial natriuretic peptide

c. Renin angiotensin system

d. aldosterone and ANP



104) Most common bacteria causing meningitis secndary to lung abcess

*streptococci

*peneumococci

*staphylococci





105) Mechanism of action of ondansetron

*5 HT3 antagonist

*dopamine antagonist at central chemoreceptor trigger zone



106) Edema fluid in acute inflammation

*contain lymphocye

*donot contain fibrinogen

*specific gravity 1.010

*protein more than 3gm

*is a transudate



107) Patient presented with lesion on nose. Lab shows proteinuria... Histopathology reveals granuloma vasculitis. Most likely diagnosis..

*Leprosy

*wegener granulomatosis



108) Median ligament is a remanant of

*umblical artery

*umblical vein

*urachus





109) In stress,level of all hormones increases except a GH b cortisol c ADH d insulin



110) A child with mental retardation,protuding tongue,umblicl hernia, upward slant of lateral canthus, hypotonia n hypermobility... Trisomy? *18 *21 *13



111) all genetic disease have common basis,it should include the defect of 1.dna 2.rna 3.nucleotide 4.mRNA



112) whats not correct about supra renal gland 1.both glands receives blood sypply only from aortic branches 2. inf phrenic artrery gives sup.suprenal artery 3.aorta supplies both gland 4.renal artery give branches to the gland



113) which vein accompany the left anterior interventricular septum artery great cardiac vein oblique vein small cardiac vein



114) nerve supply of sternocleidomastoid a)accessory b)facial c)glossopharngeal d)...



115) propagation of action potential is bcz of a increased intracellular Na+ b depolaization of membrane c ca inlux



116) which antacid slows gastric emptyng A.aluminium hydoxide B.magnesium hdroxide C.sodium bicarb



117) The transitional epithelium lining the urinary bladder is derived from (A) ectoderm (B) endoderm (C) mesoderm (D) endoderm and mesoderm (E) neural crest ..



ans : A



ref : BRS Embryology



118) Which is nt in post relatn of lesser sac *celiac ganglion *rt suprarenal gland *lt suprarenal gland *lt kidney



119) Which one is nt ant relatn of lt kidney *splenic flexure *spleen *pancreas *diaphragm *stomach





120) Most common acquired mutation in thrombotic disordr *antithrombin defeciency *protein c defeciency *protein s deficiency

Antiphopholipid syndrome



121) Which is not physiologicl function of thyroid *anabolic action on adipose tissue *catabolic action on muscle * inc metabolism of lipoprotein



122) Which is nt function of liver *cholesterol synthesis *albumin synthesis *lipogenesis *gamma globulin synthesis



123) Biguanides s/e *hypoglycemia *flatulence diarrhea



124) Infusion of large amount of dextrose in water.wht wd b inhibited *ADH *aldosterone *vasopressin *cortisol *insulin



125) Haemorrhage infarct seen in *spleen *lung with thromoembolism *liver



126) Pulse pressure increase with *aortic stenosis *heart failure *hypertensn *haemorrhage



127) Facial nerve paralysis with loss of taste sensation ant 2/3rd tongue.lesion at *facial canal *internal auditory meatus *stylomastoid foramen



128) most of the lymph is filtered by : peyer's patches lymph nodes spleen thymus



129) edema is caused by : Decreased hydrostatic pressure Increased osmotic pressure lymph obstruction



130) which route of administration of drug highly affects bio-availability? a-oral b-iv c-sc d-im e-sub lingual



131) Permanent cells are *myocardial cells *glial cells *hepatocytes



132) effect of clostridium botulinum toxin ingestion? a-fllacid paralysis of resp muscles b-vomiting c-fever



133) What is most appropriate abt thyroid gland... *parathyroid lies on superolateral surface *epithelium change acc to function *isthmus lies above cricoid cartilage



134) Patient on ATT c/o pain in joint uric acid 10 which drug must b stop *rifampicin *pyrizinamide *streptomycin



135) Leukocyte alkaline phosphatase score decrease in *CML



136) Heart sound produced by rapid ventricular filling *s3 *s4 *s1



137) a pateint has glucose level of 100mg/dl but glycosuria occurs this is due to a decrease renal threshold for glucose b proximal tubule is unable to absorb glucose c absorption in proximal tubule is decresed



138) anterior fontanelle close @ a 12 to 18 month b 18 t0 24 months



139) foot drop occur by which nerve paralysis a.tibial n b,commen peronial nerve c.post tibial n d,sciatic nerve



140) a women has been injected ppd after 24 hours there was a scar appears,and it was surrounded by macrophages and ? A.nuetophil B.basophill c.easinophill



Tcells



141) Child with peripheral edema,enlarged liver, mcv 105,dec hb... s.albumin decreased,which nutritional deficiency is the chid suffering: -marasmus -kwashiorkor -pernicioous anemia



142) which nerve cross cavernous sinus a,occullo b,abducent c,trochela d,trg



143) In trigeminal neuralgia,injection is inserted into trigeminal ganglion present in: -ant cranial fossa -post cranial fossa -middle cranial fossa -pterigopalatine fossa



144) T wave in ECG *at the begining of refractory period *during ventricuLar repoLarization



145) an elderly t, on some antihyPertensive, comes with unconj bilirubin raised! which drug is being used? methyl doPa



146) if the percentage of heart diseases is 10% and hyperlipidemias is 30% than wt will be the percentage of these two occurring together? a)0.35 b)1 c)0.37 d)0.33









147) Antibodies formed in a) Thymus b) Plasma cells c) Lymphocytes d) Spleen e) liver



148) A patient receives radiotherapy for Squamous Cell Carcinoma, some time later the there is scarring & ulceration to the skin because of:



a- Damage to the squamous epithelium b- Endarteritis obliterans c- infection d- venous thrombosis



149)Bottom of Form



150) The most significant agent in causing Cerebral Malaria:



P.vivax P.Falciparum P.malarae P.Ovale





151) Athlete is unable to rotate his foot medially(inversion) bt turns easily laterally.cause is damage to...



a.ext haluucis longus nd flexr hallucis longus b.tibialis anterior nd hallucis longus c.tibialis posterior nd extnsr hallucis longus d.tibialis ant nd flexr hallucis longus

Tibialis anterior and tibialis posterior



152) A patient with tumor in the Right Superior bronchus which segment is likely to be affected: a- Apical Superior b- Apical Basal c- Superior Basa



153) effects of morphine is prefereble in which condition. A.crf B terminal stage of cancer C biliary colic







154) Difference b/w septc and hypovolumic shock., . temperature heart rate respiratory rate pallor hypotension



155) decreased calcium levels and increased phosphate and serium parathyroid hormone increase because of a,hypoparathyroidisam b,renal failure







156) Diaphragm =

intercostals n phrenic nerves supply? 1. formed by somatic mesoderm, 2.esophagus pierce its central tendon, 3.some plexure or autonomic nerver pass thro/pierce it. ....



Tuberculous patient biopsy of lymph node done , diagnosis on a.epitheloid cell b.multinucled giant cell c.mono nucleitid cell

Caseous necrosis









157) iron is stored in parenchymal cells as A...ferritin B...hemosiderin









158) Wats true if a boy steps on needle? A. Its multisynaptic b. No interneuron c. Receptors are encapsulated



159) aglutinogens are a.antibodies b.secreted in saliva c.enzymes





160).auditory pathway...

amygdale is part new olfactory pathway

dendrites terminate on granule cells



161).Not presend in axon...

Golgi,

mitochondria,

nissl bodies



162).one q about tuberculous lesion and in option were........

antibodies transferable

antibody attached to mycobacterium

cell bound..





163) .cervicl lymph nod biopsy show difus polyclonal hyperplasia

infectious mononucleosis

brucellosis

lymphocytic lymphoma





164) .diazepam cause mescl relaxation actin on nurimscular jnctn,

cerebral cortex,

interneurons....



165) .balance of K+ in ECF and ICF maintained by-

Na-K ATPase pump



166) .wen will occcur bronchoconatriction morning

evening

night sleep

noon



167).‎41% hematocrit

41% RBCs



168) .plasma flow-

hippuric acid



169) .most impoortant for graft survuval?

ABO compatibility

HLA matching



170) .foam cels

macrophages Not part of diencephelon?





171) . Not part of diencephalon

Superior olivery nucleus

Pulvinar



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