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MCQs PHARMACOLOGY: Antiseizure drugs

Discussion in 'Exam Preparation' started by aayisha quddus, Dec 8, 2014.

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  1. aayisha quddus

    aayisha quddus Member

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    001. The mechanism of action of antiseizure drugs is: a) Enhancement of GABAergic (inhibitory) transmission b) Diminution of excitatory (usually glutamatergic) transmission c) Modification of ionic conductance d) All of the above mechanisms
    002. Which of the following antiseizure drugs produces enhancement of GABA-mediated inhibition? a) Ethosuximide b) Carbamazepine c) Phenobarbital d) Lamotrigine
    003. Indicate an antiseizure drug, which has an impotent effect on the T-type calcium channels in thalamic neurons? a) Carbamazepin b) Lamotrigine c) Ethosuximide d) Phenytoin
    004. Which of the following antiseizure drugs produces a voltage-dependent inactivation of sodium channels? a) Lamotrigine b) Carbamazepin c) Phenytoin d) All of the above
    005. Indicate an antiseizure drug, inhibiting central effects of excitatory amino acids: a) Ethosuximide b) Lamotrigine c) Diazepam d) Tiagabine
    006. The drug for partial and generalized tonic-clonic seizures is: a) Carbamazepine b) Valproate c) Phenytoin d) All of the above
    007. Indicate an anti-absence drug: a) Valproate b) Phenobarbital c) Carbamazepin d) Phenytoin
    008. The drug against myoclonic seizures is: a) Primidone b) Carbamazepine c) Clonazepam d) Phenytoin 009. The most effective drug for stopping generalized tonic-clonic status epilepticus in adults is: a) Lamotrigine b) Ethosuximide c) Diazepam d) Zonisamide
    010. Select the appropriate consideration for phenytoin: a) It blocks sodium channels b) It binds to an allosteric regulatory site on the GABA-BZ receptor and prolongs the openings of the Cl- channels c) It effects on Ca2+ currents, reducing the low-threshold (T-type) current d) It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
    011. Phenytoin is used in the treatment of: a) Petit mal epilepsy b) Grand mal epilepsy c) Myoclonic seizures d) All of the above
    012. Dose-related adverse effect caused by phenytoin is: a) Physical and psychological dependence b) Exacerbated grand mal epilepsy c) Gingival hyperplasia d) Extrapyramidal symptoms
    013. Granulocytopenia, gastrointestinal irritation, gingival hyperplasia, and facial hirsutism are possible adverse effects of: a) Phenobarbital b) Carbamazepin c) Valproate d) Phenytoin
    014. The antiseizure drug, which induces hepatic microsomal enzymes, is: a) Lamotrigine b) Phenytoin c) Valproate d) None of the above
    015. The drug of choice for partial seizures is: a) Carbamazepin b) Ethosuximide c) Diazepam d) Lamotrigine 016. The mechanism of action of carbamazepine appears to be similar to that of: a) Benzodiazepines b) Valproate c) Phenytoin d) Ethosuximide
    017. Which of the following antiseizure drugs is also effective in treating trigeminal neuralgia? a) Primidone b) Topiramat c) Carbamazepine d) Lamotrigine
    018. The most common dose-related adverse effects of carbamazepine are: a) Diplopia, ataxia, and nausea b) Gingival hyperplasia, hirsutism c) Sedation, physical and psychological dependence d) Hemeralopia, myasthenic syndrome
    019. Indicate the drug of choice for status epilepticus in infants and children: a) Phenobarbital sodium b) Clonazepam c) Ethosuximide d) Phenytoin
    020. Barbiturates are used in the emergency treatment of status epilepticus in infants and children because of: a) They significantly decrease of oxygen utilization by the brain, protecting cerebral edema and ischemia b) Short onset and duration of action c) They do not have effect on sleep architecture d) All of the above
    021. Which of the following antiseizure drugs binds to an allosteric regulatory site on the GABA-BZ receptor, increases the duration of the Cl- channels openings: a) Diazepam b) Valproate c) Phenobarbital d) Topiramate
    022. Adverse effect caused by phenobarbital is: a) Physical and phychological dependence b) Exacerbated petit mal epilepsy c) Sedation d) All of the above
    023. Which of the following antiseizure drugs is a prodrug, metabolized to phenobarbital? a) Phenytoin b) Primidone c) Felbamate d) Vigabatrin
    024. Indicate the antiseizure drug, which is a phenyltriazine derivative: a) Phenobarbital b) Clonazepam c) Lamotrigine d) Carbamazepin
    025. Lamotrigine can be used in the treatment of: a) Partial seizures b) Absence c) Myoclonic seizures d) All of the above
    026. The mechanism of vigabatrin′s action is: a) Direct action on the GABA receptor-chloride channel complex b) Inhibition of GABA aminotransferase c) NMDA receptor blockade via the glycine binding site d) Inhibition of GABA neuronal reuptake from synapses
    027. Indicate an irreversible inhibitor of GABA aminotransferase (GABA-T): a) Diazepam b) Phenobarbital c) Vigabatrin d) Felbamate
    028. Tiagabine: a) Blocks neuronal and glial reuptake of GABA from synapses b) Inhibits GABA-T, which catalyzed the breakdown of GABA c) Blocks the T-type Ca2+ channels d) Inhibits glutamate transmission at AMPA/kainate receptors
    029. The mechanism of both topiramate and felbamate action is: a) Reduction of excitatory glutamatergic neurotransmission b) Inhibition of voltage sensitive Na+ channels c) Potentiation of GABAergic neuronal transmission d) All of the above
    030. The drug of choice in the treatment of petit mal (absence seizures) is: a) Phenytoin b) Ethosuximide c) Phenobarbital d) Carbamazepin
    031. The dose-related adverse effect of ethosuximide is: a) Gastrointestinal reactions, such as anorexia, pain, nausea and vomiting b) Exacerbated grand mal epilepsy c) Transient lethargy or fatigue d) All of the above 032. Valproate is very effective against: a) Absence seizures b) Myoclonic seizures c) Generalized tonic-clonic seizures d) All of the above
    033. The drug of choice in the treatment of myoclonic seizures is: a) Valproate b) Phenobarbital c) Phenytoin d) Felbamate
    034. The reason for preferring ethosuximide to valproate for uncomplicated absence seizures is: a) More effective b) Valproate′s idiosyncratic hepatotoxicity c) Greater CNS depressant activity d) All of the above 035. The mechanism of valproate action is: a) Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABA- aminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation) b) Inhibition of voltage sensitive Na+ channels c) Inhibition of low threshold (T-type) Ca2+ channels d) All of the above
    036. Indicate the antiseizure drug, which is a sulfonamide derivative, blocking Na+ channels and having additional ability to inhibit T-type Ca2+ channels: a) Tiagabine b) Zonisamide c) Ethosuximide
    d) Primidone
    037. Indicate the antiseizure drug – a benzodiazepine receptor agonist: a) Phenobarbital b) Phenytoin c) Carbamazepine d) Lorazepam
    038. Which of the following antiseizure drugs acts directly on the GABA receptor-chloride channel complex? a) Vigabatrin b) Diazepam c) Gabapentin d) Valproate
    039. Benzodiazepine΄s uselfulness is limited by: a) Tolerance b) Atropine-like symptoms c) Psychotic episodes d) Myasthenic syndrome
    040. A long-acting drug against both absence and myoclonic seizures is: a) Primidone b) Carbamazepine c) Clonazepam d) Phenytoin
    041. Which of the following antiseizure drugs may produce teratogenicity? a) Phenytoin b) Valproate c) Topiramate d) All of the above
    042. The most dangerous effect of antiseizure drugs after large overdoses is: a) Respiratory depression b) Gastrointestinal irritation c) Alopecia d)
     
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