MCQs PHARMACOLOGY: ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER

001. All of the following antiviral drugs are the analogs of nucleosides, EXCEPT: a) Acyclovir b) Zidovudine c) Saquinavir d) Didanozine
002. Tick the drug, a derivative of adamantane: a) Didanozine b) Rimantadine c) Gancyclovir d) Foscarnet 003. Tick the drug, a derivative of pyrophosphate: a) Foscarnet b) Zidovudine c) Vidarabine d) Acyclovir
004. Tick the drug, inhibiting viral DNA synthesis: a) Interferon b) Saquinavir c) Amantadine d) Acyclovir 005. Tick the drug, inhibiting uncoating of the viral RNA: a) Vidarabine b) Rimantadine c) Acyclovir d) Didanozine
006. Tick the drug, inhibiting viral reverse transcriptase: a) Zidovudine b) Vidarabine c) Rimantadine d) Gancyclovir
007. Tick the drug, inhibiting viral proteases: a) Rimantadine b) Acyclovir c) Saquinavir d) Zalcitabine
008. Tick the drug of choice for herpes and cytomegalovirus infection treatment: a) Saquinavir b) Interferon alfa c) Didanozine d) Acyclovir
009. Tick the drug which belongs to nonnucleoside reverse transcriptase inhibitors: a) Zidovudine b) Vidarabine c) Nevirapine d) Gancyclovir
010. All of the following antiviral drugs are antiretroviral agents, EXCEPT: a) Acyclovir b) Zidovudine c) Zalcitabine d) Didanozine
011. Tick the drug used for influenza A prevention: a) Acyclovir b) Rimantadine c) Saquinavir d) Foscarnet 012. Tick the drug used for HIV infection treatment, a derivative of nucleosides: a) Acyclovir b) Zidovudine c) Gancyclovir d) Trifluridine
013. Tick the antiviral drug which belongs to endogenous proteins: a) Amantadine b) Saquinavir c) Interferon alfa d) Pencyclovir
014. Tick the drug which belongs to nucleoside reverse transcriptase inhibitors: a) Didanosine b) Gancyclovir c) Nevirapine d) Vidarabine
015. All of the following antiviral drugs are anti-influenza agents, EXCEPT: a) Acyclovir b) Amantadine c) Interferons d) Rimantadine
016. Tick the unwanted effects of zidovudine: a) Hallucinations, dizziness b) Anemia, neutropenia, nausea, insomnia c) Hypertension, vomiting d) Peripheral neuropathy
017. Tick the unwanted effects of intravenous acyclovir infusion: a) Renal insufficiency, tremors, delerium b) Rash, diarrhea, nausea c) Neuropathy, abdominal pain d) Anemia, neutropenia, nausea, insomnia
018. Tick the drug that can induce peripheral neuropathy and oral ulceration: a) Acyclovire b) Zalcitabine c) Zidovudine d) Saquinavir
019. Tick the unwanted effects of didanozine: a) Hallucinations, dizziness, insomnia b) Anemia, neutropenia, nausea c) Hypertension, vomiting, diarrhea d) Peripheral neuropathy, pancreatitis, diarrhea, hyperuricemia 020. Tick the unwanted effects of indinavir: a) Hypotension, vomiting, dizziness b) Nephrolithiasis, nausea, hepatotoxicity c) Peripheral neuropathy, pancreatitis, hyperuricemia d) Anemia, neutropenia, nausea
021. Tick the drug that can induce nausea, diarrhea, abdominal pain and rhinitis:a) Acyclovire b) Zalcitabine c) Zidovudine d) Saquinavir
022. All of the following effects are disadvantages of anticancer drugs, EXCEPT: a) Low selectivity to cancer cells b) Depression of bone marrow c) Depression of angiogenesis d) Depression of immune system
023. Rational combination of anticancer drugs is used to: a) Provide synergism resulting from the use of anticancer drugs with different mechanisms combination b) Provide synergism resulting from the use of anticancer drugs with the same mechanisms combination c) Provide stimulation of immune system d) Provide stimulation of cell proliferation
024. Tick the anticancer alkylating drug, a derivative of chloroethylamine: a) Methotrexate b) Cisplatin c) Cyclophosphamide d) Carmustine
025. Tick the anticancer alkylating drug, a derivative of ethylenimine: a) Mercaptopurine b) Thiotepa c) Chlorambucil d) Procarbazine
026. Tick the group of hormonal drugs used for cancer treatment: a) Mineralocorticoids and glucocorticoids b) Glucocorticoids and gonadal hormones c) Gonadal hormones and somatotropin d) Insulin
027. Tick the anticancer alkylating drug, a derivative of alkylsulfonate: a) Fluorouracil b) Carboplatin c) Vinblastine d) Busulfan
028. Tick the anticancer drug of plant origin: a) Dactinomycin b) Vincristine c) Methotrexate d) Procarbazine
029. Action mechanism of alkylating agents is: a) Producing carbonium ions altering protein structure b) Producing carbonium ions altering DNA structure c) Structural antagonism against purine and pyrimidine d) Inhibition of DNA-dependent RNA synthesis
030. Tick the anticancer drug, a pyrimidine antagonist: a) Fluorouracil b) Mercaptopurine c) Thioguanine d) Methotrexate
031. Methotrexate is: a) A purine antagonist b) A folic acid antagonist c) An antibiotic d) An alkylating agent 032. Tick the antibiotic for cancer chemotherapy: a) Cytarabine b) Doxorubicin c) Gentamycin d) Etoposide 033. Fluorouracil belongs to: a) Antibiotics b) Antimetabolites c) Plant alkaloids d) Bone marrow growth factor
034. Tick the action mechanism of anticancer drugs belonging to plant alkaloids: a) Inhibition of DNA-dependent RNA synthesis b) Cross-linking of DNA c) Mitotic arrest at a metaphase d) Nonselective inhibition of aromatases
035. General contraindications for anticancer drugs are: a) Depression of bone marrow b) Acute infections c) Severe hepatic and/or renal insufficiency d) All of the above
036. Action mechanism of methotrexate is: a) Inhibition of dihydrofolate reductase b) Activation of cell differentiation c) Catabolic depletion of serum asparagine d) All of the above
037. Tick the anticancer drug belonging to inorganic metal complexes: a) Dacarbazine b) Cisplatin c) Methotrexate d) Vincristine
038. Tick the indication for estrogens in oncological practice: a) Leukemia b) Cancer of prostate c) Endometrial cancer d) Brain tumors
039. Enzyme drug used for acute leukemia treatment: a) Dihydrofolate reductase b) Asparaginase c) Aromatase d) DNA gyrase
040. All of the following drugs are derivatives of nitrosoureas, EXCEPT: a) Carmustine b) Vincristine c) Lomustine d) Semustine
041. Tick the group of drugs used as subsidiary medicines in cancer treatment: a) Cytoprotectors b) Bone marrow growth factors c) Antimetastatic agents d) All of the above
042. Tick the estrogen inhibitor: a) Leuprolide b) Tamoxifen c) Flutamide d) Anastrozole
043. Tick the antiandrogen drug: a) Flutamide b) Aminoglutethimide c) Tamoxifen d) Testosterone
044. Tick the drug belonging to aromatase inhibitors: a) Octreotide b) Anastrozole c) Flutamide d) Tamoxifen
045. Tick the drug belonging to gonadotropin-releasing hormone agonists: a) Leuprolide b) Tamoxifen c) Flutamide d) Anastrozole

 

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ANSWERS
1C
2B
3A
4D
5B
6A
7C
8B
9C
10A
11B
12B
13C
14A
15A
16B
17A
18D
19B
20D
21C
22A
23C
24B
25B
26B
27D
28B
29B
30A
31B
32B
33B
34C
35D
36A
37B
38B
39A
40B
41D
42B
43A
44B
45A