MCQs PHARMACOLOGY: Chemotherapy

60.1 Which of the following neoplastic diseases is almost curable by chemotherapy:
A. Bronchogenic carcinoma
B. Choriocarcinoma
C. Malignant melanoma
D. Colorectal carcinoma

60.2 The following anticancer drug has high emetogenic potential:
A. Vincristine
B. Chlorambucil
C. 6-Mercaptopurine
D. Cisplatin

60.3 The following is true of cancer chemotherapy:
A. Anticancer drugs increase the risk of develo-ping leukaemias and lymphomas several years later
B. All anticancer drugs are highly emetogenic
C. Growth fraction of cancers is higher than any nomral tissue of the body
D. All of the above are correct

60.1 B 60.2 D 60.3 A

 

60.4 Anticancer drugs weaken host defence by:
A. Damaging respiratory and gut epithelia
B. Inducing granulocytopenia
C. Altering resident microbial flora
D. Both 'A' and 'B' are correct

60.5 Practically all antineoplastic drugs can produce the following toxic effects except:
A. Depression of leucocyte count
B. Mucositis
C. Cardiomyopathy
D. Oligozoospermia

60.6 Alkylating agents exert cytotoxic action by inducing:
A. Breakage of DNA strand
B. Cross linking of DNA strands
C. Abnormal pairing of purine and pyrimidine bases
D. All of the above

60.7 The following is true of cyclophosphamide except:
A. It is highly reactive and a vesicant on contact
B. It is a prodrug
C. It has marked immunosuppressant property
D. It frequently causes alopecia and cystitis

60.8 The most important target of action of chlorambucil is:
A. Myeloid tissue
B. Lymphoid tissue
C. Neural tissue
D. Skin

60.4 D 60.5 C 60.6 D 60.7 A 60.8 B

 

60.9 Methotrexate has the following attributes except:
A. It is cell cycle specific and kills cells in the S phase
B. Its toxicity primarily affects bone marrow and epithelial structures
C. Folic acid reverses its toxic effects
D. It is the drug of choice for choriocarcinoma

60.10 The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:
A. Busulfan
B. Vincristine
C. Cytarabine
D. Procarbazine

60.11 Vinca alkaloids exert antitumor activity by:
A. Activating topoisomerase II to cause breaks in DNA strands
B. Crosslinking DNA strands
C. Inhibiting DNA mediated RNA synthesis
D. Inhibiting polymerization of tubulin to form intracellular microtubules

60.12 The following cytotoxic drug acts by inhibiting depoly-merization of tubulin and thus producing abnormal arrays of microtubules:
A. Paclitaxel
B. Vinblastine
C. Etoposide
D. Mitoxantrone

60.13 Vincristine differs from vinblastine in the following respect(s):
A. Its prominent adverse effect is neuropathy
B. It frequently produces alopecia
C. It does not significantly depress bone marrow
D. All of the above

60.14 What is true of docetaxel:
A. It is used as a reserve drug for refractory breast and ovarian cancer
B. It is a selective estrogen receptor modulator used for breast cancer
C. It is effective only in estrogen receptor positive breast cancer
D. Both 'B' and 'C' are correct

60.15 Choose the correct statement about topotecan:
A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks
B. It is a cell cycle specific anticancer drug
C. It is a COMT-inhibitor used in advanced parkinsonism
D. Both 'A' and 'B' are correct

60.16 The characteristic toxicity of doxorubicin is:
A. Kidney damage
B. Liver damage
C. Cardiomyopathy
D. Pulmonary fibrosis

60.17 Thioguanine differs from mercaptopurine in that:
A. It is not metabolized by xanthine oxidase
B. It does not cause hyperuricemia
C. Its dose need not be reduced when allopuri-nol is given concurrently
D. Both ‘A’ and ‘C’ are correct (p. 773)

60.9 C 60.10 B 60.11 D 60.12 A 60.13 D 60.14 A 60.15 D 60.16 C 60.17 D

 

60.18 Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:
A. Dacarbazine
B. Procarbazine
C. Melphalan
D. Hydroxyurea

60.19 The following is true about use of prednisolone in malignant diseases except:
A. It is curative in acute childhood leukaemia
B. It is used in Hodgkin’s disease
C. It controls hypercalcaemia in patients with bony metastasis
D. It affords symptomatic relief in most cancer patients

60.20 The following does not apply to cancer chemo-therapy:
A. Each treatment with a cytotoxic drug kills a constant number of malignant cells
B. Drugs are generally used at maximum tolerated doses
C. The same regimen which is palliative for a large solid tumour may be curative after surgical removal of the tumour
D. Combination regimens using several drugs in succession are superior to single drug used continuously

60.21 Select the cell cycle nonspecific antineoplastic drug:
A. Vincristine
B. Bleomycin
C. Methotrexate
D. 5-Fluorouracil

60.22 Mesna is administered with cyclophosphamide and ifosphamide to:
A. Potentiate their cytotoxic action
B. Retard their renal excretion
C. Block their emetic action
D. Ameliorate cystitis caused by them

60.23 Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s):
A. To enhance antitumour activity of the drug
B. To prevent hypersensitivity reactions to the drug
C. To hasten recovery from drug induced myelo-suppression
D. Both ‘A’ and ‘C’ are correct

60.24 What is true of thalidomide:
A. It exerts antitumour activity in some solid malignant tumours
B. It ameliorates cancer associated cachexia
C. It exerts antileprotic action
D. All of the above

61.1 Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers:
A. Cyclophosphamide
B. Cyclosporine
C. Methotrexate
D. 6-Mercaptopurine

60.18 B 60.19 A 60.20 A 60.21 D 60.22 D 60.23 C 60.24 B 61.1 B