MCQs PHARMACOLOGY: Drugs of abuse

001. Psychologic dependence is: a) Decreased responsiveness to a drug following repeated exposure b) A combination of certain drug-specific symptoms that occur on sudden discontinuation of a drug c) Compulsive drug-seeking behavior d) All of the above

002. Tolerance is associated with: a) An ability to compensate for the drug effect b) Increased disposition of the drug after chronic use c) Compensatory changes in receptors, effector enzymes, or membrane actions of the drug d) All of the above

003. Addiction is associated with the existence of: a) Psychological dependence b) Physiological dependence c) Tolerance d) All of the above

004. Substances causing narco- and glue sniffings are all of the following EXCEPT : a) Stimulants b) Antipsychotic drugs c) Psychedelics d) Sedative drugs

005. Which of the following abused drugs do not belong to sedative agents? a) Barbiturates b) Tranquilizers c) Cannabinoids d) Opioids

006. Psychedelics are all of following agents EXCEPT: a) Cocaine b) LSD c) Marijuana d) Volatile substances (glues, solvents, volatile nitrites and nitrous oxide)

007. In contrast to morphine, heroin is: a) Used clinically b) More addictive and fast-acting c) More effective orally d) Less potent and long-acting

008. Symptoms of opioid withdrawal begin 8-10 hours after the last dose. a) True b) False

009. The acute course of opioid withdrawal may last: a) 3-4 days b) 7-10 days c) 3-4 weeks d) 26-30 weeks

010. Indicate the sedative-hypnotic agent, which has the highest abuse potential: a) Buspironeb) Diazepam c) Phenobarbital d) Zolpidem

011. Characteristics of barbiturate intoxication (2-3 dose) include all of the following EXCEPT: a) Pleasant feelings of the “blow” in the head, vertigo, myasthenia, stupor b) Perceptual distortion of surroundings, disorders of thinking, behavior c) Locomotive, speech excitation, sharp swings from a cheerful mood to an aggressive state d) Sleep with the subsequent weakness and headaches

012. Barbiturate abstinent syndrome is shown by: a) Crisis by 3 day of abstention b) Anxiety, mydriasis, myasthenia, muscular convulsions, vomiting, diarrhea c) Psychosis as delirium (color visual and auditory hallucinations) d) All of the above

013. Which one of the following tranquilizers belongs to strong euphorizing agents? a) Mebicarum b) Buspirone c) Diazepam d) Chlordiazepoxide

014. Tranquilizers intoxication (5-10 tablets) features include: a) Euphoria, burst of energy, increase in motor activity, wave warmth all over the body b) Visual hallucinations, a distorted feelling of time and space c) Physical bliss, body lightness, a wish to fly, motionlessness d) Synaesthesia (the sounds can be tensed, the colors can be heard)

015. Which of the following abused drugs is related to stimulants? a) Cocaine b) Amphetamine c) Caffeine d) All of the above

016. Cocaine exerts its central action by: a) Inhibiting phosphodiesterase b) Increasing a release of catecholaminergic neurotransmitters, including dopamine c) Inhibiting dopamine and norepinephrine reuptake d) Altering serotonin turnover

017. “Crack” is a derivative of: a) Opium b) LSD c) Cocaine d) Cannabis

018. Cocaine intoxication appears by: a) Short clouding of consciousness, lightness of body and a feeling of flight b) Wave warmth all over the body, physical bliss, motionlessness c) Clear consciousness, improved mood, influx of physical and spiritual forces, locomotive and speech excitation, reappraisal of personality d) All of the above 019. Which of the following stimulants is related to psychedelics? a) “ecstasy” (methylenedioxymethamphetamine) b) Cocaine c) “crack” (cocaine free base) d) Caffeine

020. Cocaine may cause: a) Powerful vasoconstrictive reactions resulting in myocardial infarctions b) The multiple brain perfusion defects c) Spontaneous abortion during pregnancy d) All of the above

021. Characteristics of cocaine abstinent syndrome include all of the following phases EXCEPT: a) Feeling of depression, irritability, confusion, insomnia (the first 3 days) b) Depression, apathy, excessive appetite, a wish to sleep (the subsequent 1-2 days) c) Psychosis as color visual and auditory hallucinations (for 3 day) d) New attack of depression, anxiety, irritability, dullness, intense thirst for cocaine (after 1-5 days improvement)

022. Overdoses of cocaine are usually rapidly fatal from: a) Respiratory depression b) Arrhythmias c) Seizures d) All of the above

023. Which of the following agents is related to hallucinogens? a) Heroin b) LSD c) Cocaine d) Opium

024. LSD produces: a) Mood swings b) Impaired memory, difficulty in thinking, poor judgment c) Perceptual distortion d) All of the above

025. LSD decreases in brain: a) 5-HT2 receptor densities b) GABAA-benzodiazepine receptor densities c) Adrenergic receptor densities d) D2 receptor densities

026. Which of the following agents is related to cannabis? a) Heroin b) Ecstasy c) Hashish d) Crack

027. The early stage of cannabis intoxication is characterized by: a) Euphoria, uncontrolled laugher b) Alteration of time sense, depersonalization c) Sharpened vision d) All of the above

028. Which of the following physiologic signs is a characteristic of cannabis intoxication? a) Bradycardia b) Reddening of the conjunctiva c) Miosis d) Nausea and vomiting

029. Industrial solvent inhalation causes: a) Quick intoxication, lasting only 5-15 minutes b) Euphoria, relaxed “drunk” feeling c) Disorientation, slow passage of time and possible hallucinations d) All of the above

030. Indicate the drugs of choice for reversing the withdrawal syndrome: a) Benzodiazepines b) Neuroleptics c) Antidepressants d) All of the above