MCQs PHARMACOLOGY:Drugs used in disorders of coagulation

Drugs used in disorders of coagulation

001. All of the following physiologic reactions are involved in the control of bleeding EXCEPT: a) Platelet adhesion reaction b) Platelet release reaction c) Activation of the antifibrinolytic system d) Triggering of the coagulation process

002. Which of the following substances is synthesized within vessel walls and inhibits thrombogenesis? a) Thromboxane A2 (TXA2) b) Prostacyclin (PGI2) c) Prostaglandin ((PGE) d) None of the above

003. All of the following groups of drugs are for thrombosis treatment EXCEPT: a) Anticoagulant drugs b) Antifibrinolitic drugs c) Fibrinolitic drugs d) Antiplatelet drugs 004. Pick out the drug belonging to anticoagulants of direct action: a) Aspirin b) Heparin c) Dicumarol d) Phenprocoumon

005. Which of the following drugs has low-molecular weight? a) Dicumarol b) Enoxaparin c) Phenprocoumon d) Heparin

006. Indicate the drug belonging to antagonists of heparin: a) Aspirin b) Dicumarol c) Dalteparin d) Protamine sulfate

007. Tick the drug used as an oral anticoagulant: a) Heparin b) Daltreparin c) Dicumarol d) Enoxaparin

008. All of the following drugs are indirect acting anticoagulants EXCEPT: a) Dicumarol b) Warfarin c) Dalteparin d) Phenindione

009. Which of the following drugs belongs to coumarin derivatives? a) Heparin b) Enoxaparin c) Dalteparin d) Warfarin

010. Heparin is effective when administred orally. This consideration is: a) True b) False 011. All of these drugs are antiplatelet agents EXCEPT: a) Aspirin b) Urokinase c) Ticlopidine d) Clopidogrel

012. The use of heparin is recommended for treatment of deep venous thrombosis. This statement is: a) True b) False

013. Mechanism of aspirin action is: a) Converts inactive plasminogen into active plasmin b) Inhibits COX and thus thromboxane synthesis c) Enhances the interaction between antitrombin III and both thrombin and the factors involved in the intrinsic clotting cascade d) Inhibits the glycoprotein IIb/IIIa complex

014. Which doses of Aspirin may be more effective in inhibiting Tromboxane A2? a) Low b) High

015. Which of the following drugs is an inhibitor of platelet glycoprotein IIb/IIIa receptors? a) Aspirin b) Clopidogrel c) Ticlopidine d) Abciximab

016. Ticlopidine is an inhibitor of ADP-induced platelet aggregation. It’s: a) True b) False

017. Which of the following drugs is fiibrinolytic? a) Ticlopidine b) Streptokinase c) Aspirin d) Warfarin

018. Mechanism of urokinase action is an inhibition of Thromboxane A2. This statement is: a) True b) False

019. Fibrinolytic drugs are used for following EXCEPT: a) Central deep venous thrombosis b) Multiple pulmonary emboli c) Heart failure d) Acute myocardial infarction 020. Indicate the drug belonging to fibrinoliytic inhibitors: a) Aminocapronic acid b) Ticlopidine c) Streptokinase d) Vitamin K

021. Aminocapronic acid is a drug of choice for treatment of: a) Acute myocardial infarction b) Bleeding from fibrinolytic therapy c) Heart failure d) Multiple pulmonary emboli

022. Tranexamic acid is an analog of aminocapronic acid. It’s: a) True b) False