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MCQs PHARMACOLOGY: Hypnotic drugs

Discussion in 'Exam Preparation' started by aayisha quddus, Dec 8, 2014.

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  1. aayisha quddus

    aayisha quddus Member

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    001. Hypnotic drugs are used to treat: a) Psychosis b) Sleep disorders c) Narcolepsy d) Parkinsonian disorders 002. Hypnotic drugs should: a) Reduce anxiety and exert a calming effect b) Induce absence of sensation c) Produce drowsiness, encourage the onset and maintenance of sleep d) Prevent mood swings in patients with bipolar affective disorders
    003. Which of the following chemical agents are used in the treatment of insomnia? a) Benzodiazepines b) Imidazopyridines c) Barbiturates d) All of the above
    004. Select a hypnotic drug, which is a benzodiazepine derivative: a) Zolpidem b) Flurazepam c) Secobarbital d) Phenobarbitone
    005. Tick a hypnotic agent – a barbituric acid derivative: a) Flurazepam b) Zaleplon c) Thyopental d) Triazolam
    006. Select a hypnotic drug, which is an imidazopyridine derivative: a) Pentobarbital b) Temazepam c) Zolpidem d) Chloral hydrate
    007. Which of the following hypnotic agents is absorbed slowly? a) Phenobarbital b) Flurazepam c) Triazolam d) Temazepam
    008. Which of the following barbiturates is an ultra-short-acting drug? a) Secobarbital b) Amobarbital c) Thiopental d) Phenobarbital
    009. Indicate the barbituric acid derivative, which has 4-5 days elimination half-life: a) Secobarbital b) Thiopental c) Phenobarbital d) Amobarbital
    010. Indicate the hypnotic benzodiazepine, which has the shortest elimination half-life: a) Temazepam b) Triazolam c) Flurazepam d) Diazepam
    011. Which of the following hypnotic drugs is more likely to cause cumulative and residual effects? a) Zolpidem b) Temazepam c) Phenobarbital d) Triazolam
    012. Which of the following hypnotic drugs increases the activity of hepatic drug-metabolizing enzyme systems? a) Phenobarbital b) Zolpidem c) Flurazepam d) Zaleplon
    013. Hepatic microsomal drug-metabolizing enzyme induction leads to: a) Barbiturate tolerance b) Cumulative effects c) Development of physical dependence d) “hangover” effects
    014. Hypnotic benzodiazepines are more powerful enzyme inducers than barbiturates. a) True b) False
    015. Indicate the hypnotic drug, which does not change hepatic drug-metabolizing enzyme activity? a) Flurazepam b) Zaleplon c) Triazolam d) All of the above
    016. Barbiturates increase the rate of metabolism of: a) Anticoagulants b) Digitalis compounds c) Glucocorticoids d) All of the above
    017. Which of the following agents inhibits hepatic metabolism of hypnotics? a) Flumasenil b) Cimetidin c) Phenytoin d) Theophylline
    018. Which of the following factors can influence the biodisposition of hypnotic agents? a) Alterations in the hepatic function resulting from a disease b) Old age c) Drug-induced increases or decreases in microsomal enzyme activities d) All of the above
    019. Which of the following hypnotics is preferred for elderly patients? a) Phenobarbital b) Flurozepam c) Temazepam d) Secobarbital
    020. Which of the following hypnotics is preferred in patients with limited hepatic function? a) Zolpidem b) Amobarbital c) Flurozepam d) Pentobarbital
    021. Indicate the mechanism of barbiturate action (at hypnotic doses): a) Increasing the duration of the GABA-gated Cl- channel openings b) Directly activating the chloride channels c) Increasing the frequency of Cl- channel opening events d) All of the above
    022. Imidazopyridines are: a) Partial agonists at brain 5-TH1A receptors b) Selective agonists of the BZ1 (omega1) subtype of BZ receptors c) Competitive antagonists of BZ receptors d) Nonselective agonists of both BZ1 and BZ2 receptor subtypes
    023. Which of the following hypnotic agents is a positive allosteric modulator of GABAA receptor function? a) Zaleplon b) Flurazepam c) Zolpidem d) All of the above
    024. Indicate a hypnotic drug - a selective agonist at the BZ1 receptor subtype: a) Flurazepam b) Zolpidem c) Triazolam d) Flumazenil
    025. Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes? a) Zaleplon b) Phenobarbital c) Flurazepam d) Zolpidem
    026. Indicate the competitive antagonist of BZ receptors: a) Flumazenil b) Picrotoxin c) Zolpidem d) Temazepam
    027. Flumazenil blocks the actions of: a) Phenobarbital b) Morphine c) Zolpidem d) Ethanol
    028. Indicate the agent, which interferes with GABA binding: a) Flurazepam b) Bicuculline c) Thiopental d) Zolpidem
    029. Which of the following agents blocks the chloride channel directly? a) Secobarbital b) Flumazenil c) Zaleplon d) Picrotoxin
    030. Which of the following agents is preferred in the treatment of insomnia? a) Barbiturates b) Hypnotic benzodiazepines c) Ethanol d) Phenothiazide
    031. Barbiturates are being replaced by hypnotic benzodiazepines because of: a) Low therapeutic index b) Suppression in REM sleep c) High potential of physical dependence and abuse d) All of the above
    032. Which of the following benzodiazepines is used mainly for hypnosis? a) Clonozepam b) Lorazepam c) Flurazepam d) Midazolam
    033. Indicate the main claim for an ideal hypnotic agent: a) Rapid onset and sufficient duration of action b) Minor effects on sleep patterns c) Minimal “hangover” effects d) All of the above
    034. Which stage of sleep is responsible for the incidence of dreams? a) REM sleep b) Slow wave sleep c) Stage 2NREM sleep d) All of the above
    035. During slow wave sleep (stage 3 and 4 NREM sleep): a) Dreams occur b) The secretion of adrenal steroids is at its highest c) Somnambulism and nightmares occur d) The secretion of somatotropin is at its lowest
    036. All of the hypnotic drugs induce: a) Increase the duration of REM sleep b) Decrease the duration of REM sleep c) Do not alter the duration of REM sleepd) Increase the duration of slow wave sleep
    037. Which of the following hypnotic drugs causes least suppression of REM sleep? a) Flumazenil b) Phenobarbital c) Flurazepam d) Secobarbital
    038. Although the benzodiazepines continue to be the agents of choice for insomnia, they have: a) The possibility of psychological and physiological dependence b) Synergistic depression of CNS with other drugs (especially alcohol) c) Residual drowsiness and daytime sedation d) All of the above
    039. Hypnotic benzodiazepines can cause: a) A dose-dependent increase in both REM and slow wave sleep b) Do not change sleep patterns c) A dose-dependent decrease in both REM and slow wave sleep d) A dose-dependent increase in REM sleep and decrease in slow wave sleep
    040. Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia? a) Triazolam b) Flurazepam c) Temazepam d) All of the above
    041. Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness, dysphoria, and mental or motor depression the following day? a) Temazepam b) Triazolam c) Flurazepam d) None of the above
    042. Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition: a) Thiopental b) Zolpidem c) Flurazepam d) Phenobarbital
    043. Which of the following statements is correct for zolpidem? a) Causes minor effects on sleep patterns b) The risk of development of tolerance and dependence is less than with the use of hypnotic benzodiazepines c) Has minimal muscle relaxing and anticonvulsant effects d) All of the above
    044. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects? a) Flurazepam b) Triazolam c) Zaleplon d) None of the above
    045. Zolpidem and zaleplon have effectiveness similar to that of hypnotic benzodiazepines in the management of sleep disorders. a) True b) False
    046. Which of the following hypnotic drugs is used intravenously as anesthesia? a) Thiopental b) Phenobarbital c) Flurazepam d) Zolpidem
    047. Indicate the usual cause of death due to overdose of hypnotics: a) Depression of the medullar respiratory center b) Hypothermia c) Cerebral edema d) Status epilepticus
    048. Toxic doses of hypnotics may cause a circulatory collapse as a result of: a) Blocking alfa adrenergic receptors b) Increasing vagal tone c) Action on the medullar vasomotor center d) All of the above
     
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  2. sarath

    sarath New Member Leecher

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    Answers of this MCQs
     
  3. sarath

    sarath New Member Leecher

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    Plz mention the answer for the MCQs for pharmacology hypnotic drugs
     
  4. Sarahgreat

    Sarahgreat Member

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    Which 3xam are these MCQs for ? PMDC? PLAB?
     
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